ACE2 Coding Variants In Different Populations And Their Potential Impact On SARS-CoV-2 Binding Affinity by Fedaa Ali, Menattallah Elserafy, Mohamed H. Alkordic and Muhamed Amin
[Do you find it as interesting as I do that the Ace2 variants of this intentionally created bioweapon (SARS-CoV-2) have almost no effect in the Ashkenazi Jewish population?] The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants’ analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively. https://www.sciencedirect.com/science/article/pii/S2405580820301072
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